- Low concentrations of silver ions are antibacterial.
- Adverse effects, symptoms of poisoning stem from the corrosive and caustic nature of silver nitrate. 75% silver nitrate had an ill effect when applied to newborn infants by mistake, instead of 1%. (1% is the same as 10 000ppm, 75% is the same as 750 000ppm)
- Silver protein is antibacterial due to the low concentrations of silver ions.
Environmental Protection Agency, Integrated Risk Information System
- The critical effect observed is a cosmetic effect, with no associated adverse health effects.
- Argyria, the critical effect upon which the RfD for silver is based, occurs at levels of exposure much lower than those levels associated with other effects of silver. (RfD is 8.9 grams in a 70 year life time or 0.35 milligrams of silver per day)
Agency for Toxic Substances & Disease registry, U.S. Public Health Service.
Toxicological Profile for Silver December 1990
- RfD is 25grams over in a 70 year life time. (Differs from above)
- Silver is non-toxic.
- Argyria is the only acknowledged severe toxic reaction and is characterized as only a “cosmetic problem”. It requires an accumulation of between 2 and 4 gms of silver to manifest argyria. The report assumed an oral retention factor of 0.04 i.e. 4% of ingested silver is retained. They assessed a total intake of 25 gms of silver over a lifetime of a 70kg male with a 4% retention giving a 1gm total body silver after 70yrs. From this baseline they worked out the RfD or daily reference dose as 0.014mg/kg/day for a 70kg male. (4) pg 3. This equates to 98 micrograms/day/70kg male.
- No adverse effects have been reported to the FDA
American Biotec Labs
- Silver is non-toxic
World Health Organization 1996
- Silver may be used in drinking water in concentrations of up to 0.1ppm (0.2mg per 2liter per day)
- Silver is non-toxic
Dean, W et al. 2001
Reduction of Viral load in AIDS Patients With Intravenous Mild Silver Protein: 3 case Studies Clinical Practice of Alternative Medicine
- Documents i.v. mild silver protein with 3 HIV patients with dramatic viral load reduction
- Side effect Jarisch-Herxheimer only
Temple University 1995
- Mild silver protein inhibits HIVirus replication on T cells.
- There is little if any toxicity.
South African Bureau of Standards 2005
MIC (minimum inhibitory concentration) for Bicosil 19ppm, a patented ionized silver product owned by Starlight Laboratories (Pty) LTD.
- In Mueller-Hinton broth
- Staphylococcus aureus -inhibited at 1.2ppm -killed at 2.4ppm
- Pseudomonas aeruginosa -inhibited at 1.2ppm -killed at 2.4ppm
- Escherichia coli -inhibited at 2.4 -killed at 4.7ppm
- Proteus vulgaris -inhibited at 2.4ppm -killed at 2.4ppm
- Candida albicans -killed 99.9% in 15minutes
- Bio-burden level -Aerobic count per 100ml, zero
- Yeast per 100ml zero
- Moulds per 100ml zero
- Bio burden level zero
- Sterility test (USP27) 14days -Complies
The Body Electric by Robert Becker
- Ionic silver has the proven ability to cause DNA to dedifferentiate or revert back to stem cells. Normally once DNA has expressed certain genes, it cannot return, so once a cell is skin, or a blood cell, it cannot morph to another cell type. Now, if you apply silver ions to a burn or an injury, the blood cells can convert to the necessary skin, nerve and other cell types as needed. Without it, they can only form scar tissue.
- So using a silver solution that has ionic content promotes healing without scarring
IDM Laboratory & Engineering Services cc. 2008
- Although Colloidal Silver and Bicosil has been shown to kill all pathogenic bacteria tested, it does not inhibit the proliferation of Lactic Acid Bacteria or any of the micro-organisms commonly known as Effective Microbes which include intestinal flora.
La-Bio Research cc (Pretoria) 2009
- Toxicity Study of Bicosil Ionized Silver(18 mg/litre)
- Acute, 14mg/kg
- 30 day test, 7mg and 14mg/kg/day
- 92 day test, 14mg/kg/day (+-1 litre per day for a 72kg person, equivalent of taking 92 litres over a 3 month period))
- No signs of toxicity or any other abnormality were found, clinically or clinico-pathologically, haematology and bio-chemistry. (Blood, liver, kidneys, hormones and electrolytes)
- No macro-pathology present.
- No colour change or deposits found.
World Health Organisation, 2003
Silver in drinking water:
- There have been no reports of argyria or other toxic effects resulting from the exposure of healthy persons to silver.
- On the basis of present epidemiological and pharmacokinetic knowledge, a total lifetime oral intake of about 10 g of silver can be considered as the human NOAEL’
- Silver may be used to maintain the bacteriological quality of drinking-water up to 0.1 mg/litre (a concentration that gives a total dose over 70 years of half the human NOAEL of 10 g), could then be tolerated without risk to health. (Assumes intake of two litres of silver-purified water per day).
How does it kill pathogens? Now we are getting into an area that is not nearly as clear cut as the above. That it does kill microbes, and disable viruses is a fact, but how it does it is still up to dispute. The following are some theories.
- Silver particles are an oxidizing catalyst, and as such oxidize pathogens killing them.
- Silver interferes with the microbe’s respiration (metabolism).
- Silver ties up or disables the sulphur in the microbe.
- Silver shorts out the electrostatic fields in the cell
Most of the above would not apply to viruses though. Instead the possibilities for disabling viruses are:
- Silver particles are an oxidizing catalyst and oxidize the virus killing it.
- Silver causes the virus DNA or RNA to revert back to being undifferentiated and without the proper expression for that host is disabled.
- Silver repairs the broken (segment of) DNA of a virus, making it complete, but no longer a functional virus which by design has an incomplete DNA.
The unique property of our Ionized Colloidal Silver is that on the one hand it is toxic to single celled pathogenic microbes (including bacteria, virus and fungus), and on the other hand it helps with the healing process of multicellular organisms (human tissue).
This is the reason it is so helpful in the treatment of burn wounds and cuts and scrapes.
Ionic Colloidal Silver is non-toxic, is efficacious against many microbes and is safe to use. It also promotes healing according to the Agency for Toxic Substances & Disease registry, U.S. Public Health Service.
Toxicological Profile for Silver December 1990, silver has a NOAEL of 25 grams according to the World Health Organizations document (1996), silver has a NOAEL of 10 grams.
As the WHO document is more recent, we will use the more conservative figure of 10 grams. This means that you can drink 555 litres of Silver Lab 18ppm Ionic Colloidal Silver spread over you entire life, or 8 litres per year for 70 years!
A Scientific Report On the Safety & Efficacy
of Ionic Colloidal Silver Below 25ppm
by Ian McQueen 
(edited 01 June 2012)
Many have benefited from colloidal silver (CS) over the years, some even learning how to make it and opening small businesses for its production and sale.
But large pharmaceutical companies have not considered colloidal silver as a viable product owing to its long history and consequent difficulty to patent.
Notwithstanding its proven use as an antimicrobial agent, most colloidal silver manufacturers and distributors have little or no understanding of the laws governing the pharmaceutical industry and make outlandish and unsubstantiated claims about various versions of the product, for which they cannot provide evidence or proof when challenged to do so. Another (and perhaps more disturbing) aspect is that most CS manufacturers do not know what they are making. An internet investigation to ascertain production methods being used revealed that one company, for example, produced CS by placing two silver electrodes in a solution and then ran a low voltage electrical current across the electrodes. It then claimed, in its advertising, that the product is not produced by an electrolytic process. Such statements will not earn the respect of relevant scientists, pharmacists or major governing bodies such as the Food and Drug Administration (FDA), Therapeutic Goods Administration (TGA) or the Medicines Control Council of SA (MCC).
The term ‘colloidal silver’ covers a wide range of silver-based preparations ranging in strength from 5 ppm (parts per million) to 750 000 ppm. These can be made electrolytically or chemically, and some of the strong solutions can be harmful. Many contain caustic silver nitrate, which could explain the reluctance of some doctors to use CS as they associate it with high strength silver compounds. Notwithstanding, products containing high silver concentrations are registered as scheduled drugs with the FDA and MCC. This report is based on ionic colloidal silver at strength below 25 ppm. 
Some products sold as colloidal silver are ionic silver products and not true colloids, the most common of which are silver hydroxide and silver oxide. Certain manufacturers questioned about this claimed they did not manufacture silver hydroxide and that their solution consisted only of pure silver+ ions and distilled water, which begs the question: what balances the positive (+) charge of the silver+ ions?
It is possible to produce genuine colloids, the most common of which is silver chloride. Although silver chloride has therapeutic value, it is unstable and, within three days, around 98.4% of the silver flocculates and settles at the bottom of the container. Other allegedly ‘pure’ silver products need a chelating agent or gel to hold them in suspension, which often hinders the mobility of the silver ions. Clumps of non-ionic silver particles also form colloids.
From observation and in vitro tests, true colloidal and ionic silver have proved therapeutically beneficial and many products are known to contain both types of silver.
Silverlab colloidal silver is manufactured according to the Hippocratic Oath principle that regimens are prescribed for the good of patients and are based on ability and judgment, without intending harm to anyone: ‘I will prescribe regimens for the good of my patients, according to my ability and my judgment, and never do harm to anyone.’ 
Silverlab Ionic Colloidal Silver
The full scientific name for Silverlab Ionic Colloidal Silver is Electrically Isolated Ionic Silver Hydrosol, produced by using a unique, specialised electrolytic method. It is a water soluble ionic silver solution ranging in concentration from below 0.1 ppm to 25 ppm and is not bonded to other chemicals or proteins. Silverlab CS is manufactured at 18 ppm and its low silver concentration, powerful characteristics (oligodynamic)  and zero causticity/toxicity make it perfectly safe to use.
The antimicrobial agent in the product is known to be free silver ions. To achieve this effect, silver ions must be available in solution at the microbial surface. Efficacy depends on the aqueous concentration of these ions. Silver ions appear to kill pathogenic micro-organisms instantly by blocking the respiratory enzyme system (energy production) as well as altering microbe DNA and the cell wall. They also appear to block T cell (TCR) receptors on the HIV virus and to stop the HIV RNA from unravelling.
The Toxicity, Safety, Efficacy and Pharmacology of Colloidal Silver 
The extracts below are taken from credible sources available to governing bodies. Source names appear in the Reference Notes section at the end of the article.
Adverse effects: symptoms of poisoning stem from the corrosive and caustic nature of silver nitrate. A 75% (instead of 1%) solution of silver nitrate applied to newborn infants by mistake had an ill effect. 
Results revealed no clinical abnormalities, macro-pathological abnormalities or micro-pathological abnormalities in any of the test groups. No animals died during the studies.
In water, at concentrations sufficient for bactericidal activity, silver does not impart taste, colour or odour and has no apparent detrimental effects on mammalian cells.
The critical effect observed is cosmetic only, with no associated adverse health effects.
Argyria, the critical effect upon which the RfD (oral Reference Dose) for silver is based, occurs at levels of exposure much lower than those associated with other effects of silver.
There are no known severe toxic reactions. Argyria is the only acknowledged effect of silver and is characterized as a cosmetic problem only. According to the EPA IRIS report, it requires an accumulation of between 2-4 g of silver for Argyria to manifest. The report assumes an oral retention factor of 0.04, which means 4% of ingested silver is retained. They based their assessment on a total intake of 25 g of silver during the lifetime of a 70 kg male, with a 4% retention, resulting in 1 g total body silver after 70 years. Based on this, they worked out the RfD or daily reference dose as 0.014mg/kg/day for a 70 kg male, equivalent to 98 micrograms/day for a 70 kg male.
A heavy metal is a member of an ill-defined subset of elements that exhibit metallic properties, which would mainly include the transition metals, some metalloids, lanthanides, and actinides. Many different definitions have been proposed—some based on density, some on atomic number or atomic weight, and some on chemical properties or toxicity. The term heavy metal has been called a ‘misinterpretation’ in an IUPAC technical report, due to the contradictory definitions and its lack of a ‘coherent scientific basis’. There is an alternative term: ‘toxic metal. . .’ (Ref. 5)
Classification of toxic metals in the internet resource Wikipedia reveals no reference to silver, which is not found in this category and, consequently, not classified as a toxic metal.
Silver is non-toxic.
Silver is non-toxic.
(Ref. 8, 31)
There is little, if any, toxicity.
In May 1989 the EPA suggested that drinking water levels of silver be not more than 1.142 mg/I.
No studies were located regarding death in humans or animals after inhalation exposure to silver or silver compounds.
No studies were located regarding death in humans or animals after oral exposure to silver or silver compounds.
No adverse events (AE) associated with the use of colloidal silver have been reported to the FDA.
It is also used as argentum metallicum in homoeopathy.
Silver may be used in drinking water in concentrations up to 0.1 ppm (0.2 mg per 2 litres per day).
Bioburden level determination of ionic colloidal silver at 19ppm:
- Aerobic count per 100 ml zero
- Yeast per 100 ml zero
- Moulds per 100 ml zero
- Bioburden level zero
Complies with sterility test (USP27) 14 days.
Whereas ionic silver inhibited pathogenic bacteria tested at 1.2 ppm and killed all pathogenic bacteria tested at 2.4 ppm, ionic silver did not inhibit or kill any of the strains of probiotic.bacteria tested even at 9 ppm.
Concentrations of colloidal silver up to 30 ppm have no inhibitory effect on molasses-based Effective Microorganism (EM) fermented products.
Low concentrations of silver ions are antibacterial.
Silver protein solutions have antibacterial properties, due to the presence of low concentrations of ionised silver, and have been used as eye drops and for application to mucous membranes. (Ref. 1)
The contact of the bacterial cell with silver zeolite, the consequent transfer of silver ion to the cell and the generation of reactive oxygen species in the cell are involved in the bactericidal activity of silver zeolite. In this study, it was concluded that silver ions play an important role for the bactericidal action of silver zeolite.
Vegetative cells of the three Bacillus species were not inactivated after 24 hrs of contact with uncoated stainless steel; in fact, viable counts of B. anthracis Sterne and B. subtilis 168 were observed to increase slightly. In contrast, vegetative cells were inactivated by at least three orders of magnitude by 24 hrs of contact with Ag (ionic) antimicrobial-coated stainless steel.
This work examined the efficacy of different forms of silver as a bactericidal agent against Escherichia coli. The minimum inhibitory concentration (MIC) for Ag (ionic) was observed to be between 0.1 mg Ag/l and 0.05 mg Ag/l following a 24-hour incubation period at 25°C. A MIC for colloidal metallic silver (Ag0) was not observed up to a total silver concentration of 82 mg Ag/l (82 ppm) – the highest concentration evaluated. These findings suggested cationic Ag(I) or Ag(I) complexes were responsible for the bactericidal activity of silver. It is therefore the ionic form of silver that is bactericidal.
Minimum inhibitory concentration of ionic colloidal silver 19 ppm, manufactured by Silverlab, according to its standard protocol: ionic silver, 19 ppm In Mueller-Hinton broth.
Staphylococcus aureus inhibited at 1.2 ppm and killed at 2.4 ppm
Pseudomonas aeruginosa inhibited at 1.2 ppm and killed at 2.4 ppm
Escherichia coli inhibited at 2.4 ppm and killed at 4.7 ppm
Proteus vulgaris inhibited at – and killed at 2.4 ppm
Our experiments showed that the contact antimicrobial activity of Ag (e) (electrically isolated silver) was superior to that of AgNO3 against gram-positive and gram-negative bacteria, C. albicans, and a filamentous mycete. Even though Ag(e) and Ag+, from inorganic salts, have similar, apparently membrane-related activities, the microbicidal activity of silver is significantly ion-influenced. Anodic silver ions are very effective agents at low concentrations, without any detrimental effect upon normal mammalian cells, and the concentrations needed to inhibit the bacteria in in vitro experiments have been confirmed by clinical data. Our experimental results confirm the potential of Ag (e) for use as a preservative; this anion-free preservative system might show a reduced interference with the other materials used in most formulations.
Effects of ionic colloidal silver 19 ppm on Candida albicans, manufactured by Silver Lab according to its standard protocol:
Candida albicans killed 99.9% in 15 minutes.
The product displays activity against Candida albicans in a dose-dependent manner.
Documents intravenous mild silver protein in three HIV patients, with dramatic viral load reduction.
Mild silver protein inhibits HI Virus replication on T cells.
Overt cell death is not evident with both cell lines (irrespective of ionised Ag concentration).
It appears that cell proliferation is decreased in the presence of the ionised silver, which implies a cytostatic effect rather than a cytotoxic effect.
Regular application of the product directly onto lesions may lead to eventual death of tumour cells if the cellular proliferation is inhibited long-term.
Lack of toxicity to these cell lines may also be seen as a positive confirmation of the lack of general toxicity by the ionised Ag preparation used in this study.
The cytotoxic effect of ionised Ag was most pronounced on MOLT-4 and K562 cells, increasing the dead cells to 53% and 83% respectively at a final concentration of 4.503 ppm. Although Jurkat and HL60 cells were less sensitive to the effects of ionised Ag, its influence was still noteworthy.
Ionised Ag had a potent effect on non-stimulated PBMCs, when one would have expected the opposite since these cells are not proliferating. We cannot conclude whether the oral intake of the product will demonstrate the same anti-cancer activity because the in vitro results cannot be extrapolated to in vivo situations: metabolic transformation of the product, oral uptake, etc. However, it remains an interesting product to consider for further research.
The results obtained clearly show the anti-inflammatory action of ionised Ag in vitro. At a final concentration of 4.503 ppm (25%) ionised Ag was able to inhibit the production of IL-6 and TNF-α around 5 times compared with the stimulated control. This anti-inflammatory activity was still demonstrated at a final Ag concentration of 1.126 ppm (6.25%) and inhibited the release of the cytokines by a factor of 3.
These results indicate a potential clinical use of the product to control tissue damage in chronic inflammatory conditions.
The electrically generated silver ion solution exhibited good bactericidal efficacy against S. aureus and E. coli.
These findings suggest that the use of the silver ion solution may have valuable applications in various fields, such as the manufacture of household appliances and medical devices.
The bactericidal effects of silver have been known since the mid-1800s.
Given contact times on the order of hours, silver has been shown to be somewhat effective as a disinfectant against coliforms and viruses.
Silver’s antimicrobial effect has been demonstrated in numerous applications against different types of microorganisms. The bactericidal efficacy of silver is through its binding to disulfide or sulfhydryl groups in cell wall proteins. Silver also binds to DNA. Through these binding properties, metabolic processes are disrupted, leading to cell death.
EFTEM observations demonstrated that the silver ion readily infiltrates the interior of E. coli, contrary to the early hypothesis that it resides initially in the cell membrane area. Furthermore, 2-DE and MALDI-TOF MS indicated that the expression of a ribosomal subunit protein, as well as that of some other enzymes and proteins, is affected by the silver ion. The present results demonstrate, for the first time, that one of the major bactericidal functions of the silver ion is its interaction with the ribosome and the ensuing inhibition in expression of the enzymes and proteins essential to ATP production.
How does colloidal silver kill pathogens? The following are some theories:
- Silver particles are an oxidising catalyst and, as such, oxidise and kill pathogens.
- Silver interferes with the microbe’s respiration.
- Silver ties up, or disables, the sulphur in the microbe.
- Silver shorts out the electrostatic fields in the cell.
Most of the above would not apply to viruses, though. Instead, the possibilities for disabling viruses are:
- Silver particles are an oxidising catalyst and oxidise the virus killing it.
- Silver causes the virus DNA or RNA to revert to being undifferentiated and is disabled without the proper expression for that host.
- Silver repairs the broken segment of the DNA of a virus, making it complete but no longer a functional virus which, by design, has an incomplete DNA.
Medical literature shows that a variety of viruses have been successfully treated with silver-based drugs. However, ‘silver salts’, and/or inferior silver preparations, lack the bio-availability, active silver content, and safety needed to be effective. State of the art, electrolytically produced oligodynamic Ag+, however, offers distinct advantages and versatility of use over older and cruder formulations. Possessing much smaller, sub nanometre-sized particles, greater electrical potential and lower concentrations, it is more bio-available than other formulations. Efficacy against the SARS-related coronavirus, for example, may be enhanced when nebulized Ag+ is inhaled. This should achieve swift reduction of viral loads, especially in the early stages. Moreover, there is no known toxicity for oligodynamic Ag+ in humans. The only known mechanism of resistance also appears to play no role, notwithstanding the mutability of the coronavirus. Therefore no functional barrier to the virotoxic effects of oligodynamic Ag+ may be expected, regardless of the rapidity or variety of mutations.
Like bacteria and fungi, infectious viral organisms may have multiple susceptibilities when encountering oligodynamic Ag+. On the other hand, evidence suggests that oligodynamic Ag+ will not interfere with normal white blood cell (WBC) activity, and may even enhance WBC activity. Feng, et al. concluded that oligodynamic Ag+ offered profound immune benefits because of its ability to intervene with select bacteria in three key ways almost simultaneously. Central to all three is the ability of oligodynamic Ag+ to denature (dose-dependent permanent inactivation) essential microorganisms’ protein and DNA.
One type of essential protein maintains the integrity of the cell’s membrane and boundaries. Once the membrane becomes unstable, the cells begin to rupture.
Simultaneously, the smallest sizes of Ag+ may more easily penetrate the membrane pores of bacteria. Once penetration occurs, life-essential enzyme reactions governing cell metabolism go into partial or full arrest.
As the silver further penetrates the most interior recesses of the cell, the genetic building blocks (nucleic acids) of the germs are paralysed, ending the ability of the invaders to replicate.
Delivery of active Ag+ is the key to success. Providing that delivery of oligodynamic Ag+ to the viral foci is accomplished, the effective dosage level of pure oligodynamic Ag+ is essentially medically benign to human cells. As Berger, et al. concluded, oligodynamic Ag+ generated electrically at target tissue area is observed to be very effective immune intervention at low concentrations, yet appears to cause no harm to normal mammalian cells.
The comprehensive reports above provide clear, unambiguous evidence that Silverlab Ionic Colloidal Silver is an effective treatment against many disease-inducing microbes, as well as being perfectly safe to use. Scientifically manufactured and administered according to recommended dosages, its inherent powerful medicinal qualities can provide complementary or alternative treatment for many ailments and diseases. Silver has long performed a vital role in the human body but modern chemical-ridden foods, such as fruit and vegetables, have resulted in a serious decline of silver content, which research has warned as dangerously unhealthy because of the link between the body’s falling silver levels and illness. Mankind is urged to consider its use, not only for its therapeutic value but as a tonic and prophylactic.
Preamble to Notes
Tests undertaken by the following reference sources, cited in Reference Notes, used ionic colloidal silver 18 ppm or 19 ppm, manufactured by Silverlab, according to its standard protocol:
- Martindale Pharmacopeia, 34th edition, p. 1746.
- Daan Goosen, ’90-day toxicity study performed on Sprague rats at a dose of 14ml/kg per day with 18 ppm ionic colloidal silver manufactured by Silverlab Colloidal Silver,’ La-Bio Research, Tshwane University of Technology, 30 April 2009.
- Michael A. Butkis, Michael P. Labare, Jeffrey A. Starke, King Moon and Mark Talbot, ‘Use of Aqueous Silver to Enhance Inactivation of Coliphage MS-2 by UV Disinfection,’ Applied and Environmental Microbiology, May 2004, Vol. 70, pp. 2848-2853.
- US Environmental Protection Agency, Integrated Risk Information System, Silver (CASRN 7440-22-4), last revised 12 January 1996.
- Wikipedia, Heavy metals (chemistry), accessed 18 October 2010.
- Wikipedia, Toxic metals, accessed 18 October 2010.
- American Biotec Labs.
- World Health Organisation, ‘Silver in Drinking-water – Background document for development of WHO Guidelines for Drinking-water Quality,’ Geneva (2003).
- Professor Helen R. Buckley PhD, School of Medicine, Temple University, 2 February 1995.
- FDA, Public Health Service, Centre for Drug Evaluation and Research, File F99-22589, 3 November 1999.
- South African Bureau of Standards Commercial, ‘Bioburden Level Determination performed on Ionic Colloidal Silver 19 ppm,’ (November 2005).
- South African Bureau of Standards Commercial, ‘Sterility of Ionic Colloidal Silver 19 ppm,’ (October 2005).
- Ian McQueen, IDM Laboratory & Engineering Services, ‘Effects of Silverlab Ionised Silver 18 ppm on a variety of Probiotic Bacteria,’ (May 2010).
- Vinny Pinto, ‘Effects of Ionic Colloidal Silver on Probiotic, life-giving microbes,’ Fermentation with Syntropic Anti–oxidative Microbes (2004).
- Yoshinobu Matsumura, Kuniaki Yoshikata, Shin-ichi Kunisaki and Tetsuaki Tsuchido, ‘Mode of Bactericidal Action of Silver Zeolite and its comparison with that of Silver Nitrate,’ Applied and Environmental Microbiology (July 2003), Vol. 69 (7), pp. 4278-4281.
- Belinda Galeano, Emily Korff and Wayne L. Nicholson, ‘Inactivation of Vegetative Cells, of Bacillus anthrasis, B. cereus, and B. subtilis on Stainless Steel Surfaces Coated with an Antimicrobial Silver- and Zinc-Containing Zeolite Formulation, Applied and Environmental Microbiology (July 2003), Vol. 69, pp. 4329-4331.
- Butkus, M.A. (US Military Academy), Labara, M.P. (US Military Academy) and Edling, L. (GeoTrans Inc., USA), ‘The efficacy of silver as a bactericidal agent: advantages, limitations and considerations for future use,’ Vol 1ss, pp. 407-415.
- South African Bureau of Standards Commercial, ‘Minimum Inhibitory Concentration of Ionic Colloidal Silver 19 ppm,’ (December 2005).
- N. Simonyeti, G. Simonyeti, F. Bougnoi and M. Scalzo, ‘Electrochemical Ag+ for Preservative Use,’ Applied and Environmental Microbiology (December 1992), Vol. 58, pp.3834-3836.
- South African Bureau of Standards Commercial, ‘Effects of Ionic Colloidal Silver on Candida albicans,’ (December 2005).
- Professor Patrick Bouic, ‘Effects of Ionised Silver 18 ppm on Candida albicans,’ Synexa Life Sciences (June 2007).
- Dean, W. et al, ‘Reduction of Viral Load in Aids Patients with Intravenous Mild Silver Protein: 3 Case Studies,’ Clinical Practice of Alternative Medicine (2001).
- Professor Patrick Bouic, ‘Effects of Ionised Silver 18 ppm on 2 Melanoma cell lines,’ Synexa Life Sciences (July 2007).
- Professor Patrick Bouic, ‘Effects of Ionised Silver 18 ppm on 4 cancer types and PBMCs,’ Synexa Life Sciences (July 2007).
- Professor Patrick Bouic, ‘Anti-inflammatory activity of Ionised Silver 18 ppm,’ Synexa Life Sciences (July 2007).
- Woo Kyung Jung, Hye Cheong Koo, Ki Woo Kim, Sook Shin, So Hyun Kim and Yong Ho Park, ‘Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia coli,’ Applied and Environmental Microbiology (April 2008), Vol. 74, pp. 2171-2178.
- Nadia Silvestry-Rodriguez, Kelly R. Bright, Donald C. Slack, Donald R. Uhlmann and Charles P. Gerba, ‘ Silver as a Residual Disinfectant to Prevent Biofilm Formation in Water Distribution Systems,’ Applied and Environmental Microbiology (March 2008), Vol. 74, pp. 1639-1641.
- Mikihiro Yamanaka, Keita Hara and Jun Kudo, ‘Bactericidal Actions of a Silver Ion Solution on Escherichia coli, Studied by Energy-Filtering Transmission Electron Microscopy and Proteomic Analysis, Applied and Environmental Biology (November 2005), Vol. 71, pp. 7589-7593.
- John Marshall Dudley, ‘The Chemical and Physical Basis of the Therapeutic Value of colloidal forms of silver,’ from a colloidal silver research paper.
- Eric J. Rentz, DO COMM CNMO, ‘Viral pathogens and Severe Acute Respiratory Syndrome: Oligodynamic Ag+ for Direct Immune Intervention,’ Journal of Nutritional & Environmental Medicine (June 2003), Vol. 13 (2), pp. 109-118.
- John Barltrop, MA PhD DSc and Dr R.C. Renlund, ‘Toxicity of Mild Silver Protein,’ 27 January 1995.
- Agency for Toxic Substances & Disease Registry, US Public Health Service, Toxicological Profile for Silver (December 1990).
 As manufactured and distributed by Silverlab and also generally referred to as Electrolytically Isolated Silver (EIS), Oligodynamic Silver, Hydrosol of Silver, Nano Silver, Positively Charged Ionic Silver or Colloidal Silver.
 Published 25 October 2010.
 For generations silver has been used for its antimicrobial properties to prevent and treat a variety of diseases, most notably infections. The Food and Drug Administration has approved silver solutions since the 1920s for use as antibacterial agents.
 Denotes parts of silver per million parts of water.
 The Hippocratic Oath is an oath taken by doctors swearing to practice medicine ethically. It is widely believed to have been written by Hippocrates, traditionally regarded as the father of western medicine, in the late 5th century BC.
 Oligodynamic – powerful in small quantities.
 As Silverlab Ionic Colloidal Silver is classified as a complementary medicine, the company makes no strong medical claims for its efficacy, stating frequently on its packaging ‘may help with. . .’ But this should not be construed the company suggests the product is ineffective.
 A 1% solution is equivalent to 10 000 ppm, and a 75% solution is equivalent to 750 000 ppm.
 Taken from a 90-day study performed on Sprague rats at a dose of 14ml/kg per day using Silverlab 18 ppm CS, which is equivalent to a 71 kg person drinking 90 litres of CS over a 3-month period.
 To reach 1 gm of accumulated CS, one must consume 1 388 litres of Silverlab Colloidal Silver at 18 ppm, which would place one at around a quarter of the way to the 2-4 g maximum. By contrast, only 2.5 litres of a 1% (10 000 ppm) solution would take a 70 kg man to the same level of retained silver. The World Health Organisation (WHO) conservatively recommends not more than 10 g total intake in a lifetime, equivalent to 555 litres of 18 ppm colloidal silver.
 ‘Silver preparation. . . effective in inhibiting and killing strains of candida albicans and cryptococcus neoformans from 0.7 ppm in vitro.’ Professor Helen R Buckley, School of Medicine, Temple University, 2 February 1995.
 Equal to 1.142 parts of silver per million parts of water – or ppm.
 Effective Microorganisms are a mixture of probiotic microbes including lactic acid bacteria, actinomycetes and phototropic non-sulphur bacteria.
 The only side effect would be symptoms of detoxification that may include headache and sluggishness in the body for a few days. This effect is known as the Jarisch Herxheimer Reaction.
8 Prevalent Myths & Misconceptions
About Colloidal Silver
by Steve Barwick, The Silver Edge
Lately, there’s been more misinformation on colloidal silver going around than I’ve seen since the FDA first instituted their failed campaign to ban it back in the late 1990’s.
People seem to be “salting” various news and social networking forums with this misinformation, in an attempt to get it passed around the internet and posted on even more forums.
This, of course, is a classic campaign to get misinformation about colloidal silver to go “viral,” meaning to get it passed around unwittingly by others who think they’re doing the world a favor by posting the latest “facts” on colloidal silver.
In reality, they are posting myths about colloidal silver that have been purposely concocted by shills for certain groups that have a vested interest in seeing colloidal silver defamed (think Big Pharma).
Here then, are some of the current myths making the internet rounds:
Myth #1: Children Are Being Harmed by Colloidal Silver
First, we saw the Friends of the Earth environmentalist group come out with their new position paper calling for a total ban on the over-the-counter sales of colloidal silver products as well as EPA regulation of all products using silver as an antimicrobial agent. And why? Because, they claimed, the proliferation of silver-based antimicrobial products is depriving children of coming into contact with the requisite number of pathogens needed to stimulate their tiny immune systems. Of course, it’s an unbelievable claim at face value. After all, little kids eat dirt. They roll around in the grass and dirt all day, throw mud balls at each other, play baseball in empty lots, climb trees, swim in lakes and rivers, play on dirty floors, climb into dumpsters in search of “treasure,” and do all of the things needed to put them into contact with hundreds of billions of microorganisms every single day of their lives. Yet the Friends of the Earth — with a straight face, mind you — presented as a reason to ban colloidal silver and other silver-based products the idea that kids’ immune systems were being developmentally deprived thanks to the proliferation of so many silver-based products. And this new myth is now being picked up in forums across the internet, and used as “evidence” that colloidal silver is harmful. Clearly, these guys at the Friends of the Earth have never had children.
Myth #2: Colloidal Silver Has Been “Banned by the FDA”
Then we had the recent MSNBC news article written by reporter Mike Celizic which declared that the FDA had “banned colloidal silver” back in 1999. Of course, nothing could be further from the truth. What the FDA did was prohibit colloidal silver vendors from labeling their product as a “natural antibiotic” and restrict colloidal silver advertisers from talking about its powerful antimicrobial qualities in advertisements. This action, of course, led to more public interest in colloidal silver than it had ever enjoyed in its entire 100 year history, and propelled colloidal silver into one of the most popular nutritional supplements of all times. Celizic’s erroneous contention, however, has now been picked up by other writers and spread across a variety of internet forums where it is being used by opponents of natural health to convince people not to use colloidal silver because it’s been “banned by the FDA.”
Myth #3: Colloidal Silver Causes a “Cytokine Storm”
Next, we had a famous internet doctor claim that colloidal silver could cause a potentially deadly “cytokine storm” (massive inflammation) in the lungs of even healthy individuals. The doctor presented no evidence whatsoever for his claim. And a quick search of the available medical data demonstrated that the only significant research done on colloidal silver and cytokines showed that silver actually modified cytokine expression and reduced inflammation. The authors of the medical study even stated that colloidal silver should be further investigated as a potential treatment for the massive inflammation caused by the “cytokine storm” phenomena. The famous internet doctor later removed the erroneous statement from his web site, but not before other writers spread it all over the internet as “evidence” that colloidal silver usage can have potentially “deadly” consequences.
Myth #4: Colloidal Silver Harms Human Cells
We also recently saw the old “colloidal silver harms human cells” myth being dredged up again. Once more, the culprit was the environmental group Friends of the Earth, which erroneously attributes medical research demonstrating that silver damages bacterial cells (i.e., e. coli cells) as evidence that silver damages human cells. Of course, they can’t explain how Dr. Robert O. Becker of Syracuse Medical University was able to conduct all of those now famous in vivo (i.e., in the body) medical studies on human subjects, in which he used an electronic device to drive billions of tiny silver particles deep into the infected tissue and bone of “incurable” victims of osteomyelitis, and managed to cure every one of them without causing any harm whatsoever to their cells. Certain other internet writers have also misinterpreted a recent test tube study demonstrating that high levels of silver in the blood stream could harm certain human cells. The levels used in these lab tests would have been the equivalent of 15 ppm in the human blood stream – a level you couldn’t reach without drinking gallons of a standard colloidal silver solution. The bottom line is that contrary to the assertions of the environmentalists, a recent study conducted by researchers at the Department of Neurobiology, Institute of Anatomy, at the University of Aarhus in Denmark, and published in the journal Histochemistry and Cell Biology (5 April 2008) has demonstrated that the human body has a specific process for sequestering and detoxifying accumulated silver and preventing it from harming human cells. This puts the lie to the contentions of the environmentalists who claim that silver damages human cells.
Myth #5: Colloidal Silver Causes Hardening of the Arteries
Honestly, I don’t know where in the world this one came from. But suddenly it’s cropping up on web sites all over the place, with no documentation whatsoever to back it up. As usual, it appears that one writer is simply quoting another, who is then quoted by another and another, until a complete fallacy becomes “reality.” Several weeks ago I googled “colloidal silver and hardening of the arteries” and “colloidal silver and arteriosclerosis” and searched for several hours. I couldn’t find a solid piece of medical documentation for the claim that colloidal silver causes hardening of the arteries, except for the regurgitated and unattributed claims in those articles. I also searched the various medical science news sites (even the ones that are routinely critical of silver) and couldn’t find any references to it causing artery problems. What’s more, I hired a pharmaceutical consultant to track down the origin of this growing myth. He searched the PubMed database and other key medical study databases, and could find absolutely nothing indicating any negative connection between colloidal silver and arteriosclerosis, or hardening of the arteries. We did find a recent study published in the prestigious medical science journal ACS Nano, demonstrating that silver stops red blood cells from clumping, which would help prevent heart attacks and strokes rather than cause them. You can read about that study here. So at this point my conclusion is that someone just made up the claim out of whole cloth, and it is getting passed around the internet by people too lazy to do any fact-checking or to demand documentation.
Myth #6: Colloidal Silver Causes Harm to Kidneys
This pervasive myth, along with Myth #7 below, is being cited in a variety of news articles on the internet, as well as by environmental groups like Friends of the Earth that are working to force the EPA to regulate colloidal silver products as “pesticides.” Both of these myths are unfounded. As Dr. Gary Connett wrote in the Journal of the Royal Society of Medicine in 2007, “Case reports have described possible nephrotoxicity and neurotoxicity, but these have not been substantiated by studies in animal models.” (See J R Soc Med 2008: 101: S51–S52. DOI 10.1258/jrsm.2008.s18012.) In other words, doctors have speculated that silver usage has caused harm to human kidneys and the human nervous system based on individual case reports, but that speculation has not been proven to be true when silver is actually tested. Silver given to animals during medical studies has shown no significant harm to the kidneys, liver or nervous system of the animals. And it could not be definitively demonstrated that silver was the actual culprit in the few individual human cases that led doctors to speculate that silver may have nephrotoxic or neurotoxic properties. In short, there is no significant evidence that silver harms the liver or the nervous system.
Myth #7: Colloidal Silver Causes Harm to the Nervous System
See Myth #6 above. Again, numerous internet “news” reports cite this myth, but there are to date no studies proving it. It is all based upon speculation, from a few single cases in which doctors made assumptions that later could not be proven to be true in animal studies. According to a study titled “Critical Observations on the Neurotoxicity of Silver,” published in Critical Review of Toxicology (2007;37:237-50) “Although silver is metabolized throughout the soft tissues, available evidence from experimental animal studies and human clinical reports has failed to unequivocally establish that it enters tissues of the central nervous system or is a cause of neurotoxic damage…No evidence is available to demonstrate the toxic risk of silver to the peripheral nervous system…Transitory silver sulfide deposits seen in the tissues of the blood-brain and blood-CSF barriers are mostly lysosomally bound or deposited on basement membranes or collagen without toxic effect. Silver is mostly excreted from the body in the urine and feces.” In other words, in animal studies and human clinical reports, there is no evidence that silver causes harm to the human nervous system.
Myth #8: Colloidal Silver Causes Cancer
This myth is being promulgated chiefly by one of those fake internet “doctors” who is pushing high-dose vitamin C therapy to help prevent infections. Now, I’m not against high-dose vitamin C therapy, but I am against people pretending to be doctors when they’re not. And I’m certainly against people who promulgate outright lies, such as the lie that colloidal silver causes cancer. This myth originally circulated in the 1970’s after some scientists surgically implanted silver discs under the skin of animals, and saw that sarcomas (soft tissue cancer tumors) later developed. So they announced to the world that silver causes cancer. Later, when more level-headed researchers looked into the situation, they discovered that just about anything surgically implanted under the skin would induce sarcomas, i.e., glass, plastic, ivory, wood, etc. This is due to a phenomena called “solid state carcinogenesis.” In other words, it wasn’t the silver at all, but the normal effect of just about anything being implanted directly under the surface of the skin. The Environmental Protection Agency later jumped into the fray, looking for another reason to regulate silver, but after reviewing the existing medical and scientific documentation the agency had to conclude, “No evidence of cancer in humans has been reported despite frequent therapeutic use of the compound [i.e., silver] over the years.” In other words, there are no cases of colloidal silver-induced cancers reported in the medical or scientific literature. Quite the contrary, researchers Furst and Schlauder later conducted animal studies designed to avoid the possibility of solid state carcinogenesis. They found that silver injected intramuscularly once a month into rats did not induce cancer.
Next Myth: Colloidal Silver Causes Global Warming?
Next, they’ll probably claim that colloidal silver causes global warming.
After all, it takes electricity to make colloidal silver. And electricity is generated through coal fire plants. And coal fire plants put “greenhouse gases” into the atmosphere. And “greenhouse gases” ostensibly rip holes into the ozone layer allowing excessive ionizing radiation from the sun to come streaming into our atmosphere resulting in warmer temperatures.
So there you have it. We must ban colloidal silver because it causes global warming. Seals are dying in Antarctica because thoughtless, greedy, uncaring natural health lovers are using colloidal silver.
No. Wait. For the sake of the children, we must ban colloidal silver because the FDA has already banned it. No. Wait. We must ban it because it can cause a “cytokine storm” and harm human cells. And that causes global warming. No. Wait…
…Oh, whatever. Just ban it because Big Pharma and the environmentalists hate it. At least that would be honest.
Copyright 2011 – Steve Barwick, The Silver Edge.